Sydney: New research have found four new anti-cancer compounds to inhibiting the growth of tumours.
Author Jason Smith doing his M.Phil. in biomolecular sciences from Macquarie University, undertook a comprehensive study that combined existing knowledge of an enzyme with a specifically tailored computational chemistry approach to identify novel inhibitors.
The enzyme (indoleamine 2,3-dioxygenase) has generated excitement amongst researchers over the last decade due to its increasingly recognised role as a drug target, particularly in cancer.
Over the past 10 years, scientists have learnt that compounds inhibiting this enzyme allow the immune system to attack cancer cells, the journal Bio-organic and Medicinal Chemistry reported.
After conducting virtual screening of a database of almost 60,000 compounds, Smith found 18 compounds that could potentially act as inhibitors of this enzyme.
He then tested them and found four compounds with particularly exciting prospects.
“Computational chemistry means we don`t have to spend years testing thousands of compounds in the lab,” he said.
“We can analyse all the potential compounds and narrow them down in a matter of six month`s preparation and virtual screening, instead of years. In fact, after all the preparation and groundwork, the screening itself takes around 100 hours,” he further added.
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